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8.C.e <br />exposed subgroup, non -nursing infants less than one year old, has an ARC <br />which represents 49% of the RID. Diquat dibromide's chronic dietary risk is <br />therefore considered minimal. <br />Occupational and Residential Exposure <br />Based on current use patterns, workers (mixers, loaders, applicators, and <br />other handlers) may be exposed to diquat dibromide during and after <br />application in agricultural and other settings. During large-scale applications, <br />the highest potential exposure and risks are to mixers and loaders using open <br />systems to support aerial applications (their dermal Margin of Exposure <br />(MOE) is 71, less than the 100-fold margin considered acceptable). Using <br />closed systems, their dermal MOE is 400. EPA therefore is requiring closed <br />mixing/loading of diquat dibromide for aerial applications. <br />For applicators participating in large-scale applications and for all <br />workers (including homeowners) participating in small-scale applications, <br />MOEs are greater than 100. <br />Post -application exposure to diquat dibromide residues on treated <br />foliage is a concern. For uses within the scope of the Worker Protection <br />Standard for Agricultural Pesticides (WPS), EPA is requiring a longer interim <br />Restricted Entry Interval (REI) and more stringent personal protective <br />equipment (PPE) than usual, to reduce potential exposure and risk (see Risk <br />Mitigation below). <br />For uses outside the scope of the WPS, post -application exposure risks <br />also are posed. For example, golf course workers who have substantial <br />physical contact with treated turf have a MOE of 13, 24 hours after <br />application. At four days post -application, the MOE rises to 105. Therefore, <br />a four -day reentry interval is being recommended for these workers. To <br />reduce the potential for post -application residential exposure, spot treatments <br />will be acceptable but broadcast treatments will be prohibited. Swimmers <br />may be exposed to diquat dibromide residues in treated lakes and ponds, <br />however their estimated MOE of 1,250 is acceptable. <br />Human Risk Assessment <br />Diquat dibromide is of moderate acute toxicity causing acute dermal <br />toxicity and primary eye irritation (Toxicity Category II). It is classified as a <br />Group E carcinogen, indicating that it poses no known cancer risk for <br />humans. Diquat dibromide causes developmental and reproductive toxicity at <br />the highest dose levels tested. Human incident data from California and other <br />sources were considered in evaluating diquat dibromide's risks. <br />Although people may be exposed to residues of diquat dibromide <br />through their diets, the chronic dietary risk from such exposure is minimal. <br />EPA is concerned about worker exposure to diquat dibromide during aerial <br />spray operations, and is requiring use of closed systems to mitigate potential <br />risks. The Agency also is concerned about post-application/reentry exposure <br />for uses both within and outside the scope of the WPS. EPA therefore is <br />imposing stringent reentry restrictions and protective clothing requirements <br />Attachment: EPA Facts (2109 : Dukes Root Control) <br />4 <br />Packet Pg. 58 <br />